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Так ты весьма опытный алхимик... Я раньше МОГУЩЕСТВА ТРЕДЫ на дваче создавал - но там одни скучные профаны. Думаю у нас может сложится интересный дискурс. Расскажи про агомелатин и пирибедил. С твоей оценкой бромокриптина не соглашусь - это отилчный препарат для сушки и метаболизма в целом т.к. действует как сильный миметик лептина если с утра принимать, поэтому его сейчас для лечения диабета используют.
Кстати, ты знал что у эксеместана есть предотвращающие старение свойства? Снижая уровень эстрогена - он предотвращает инволюцию тимуса.
> Aromatase inhibitors regenerate the thymus in aging male rats
https://www.sciencedirect.com/science/article/pii/0192056192901152
"...The thymus can be regenerated in aging rats by surgical or chemical castration and regeneration is inhibited by testosterone, which may exert this effect, at least in part, through its conversion to estradiol. An attempt has been made to regenerate the thymus in intact aging rats using inhibitors of the aromatase system, in the hope that this maneuver could lead to the use of such chemical intervention in the treatment of immunodeficiency syndromes. Young adult and aging (18-month-old) male rats were orchidectomized under ether anesthesia and 7 days later given s.c. implants of testosterone in silicone elastomer (SILASTIC) tubing. Some rats received testosterone together with a five-fold excess of the aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD). One group of young intact rats received implants containing 25 mg ATD and group of 18-month-old intact rats received 125 mg ATD or 25 mg of another, more powerful aromatase inhibitor 4-hydroxyandrostenedione (4-OH). On the 28th day after implanting, rats were killed and the thymus, spleen, prostate gland and seminal vesicles removed for weighing and histology. In addition, estrogen receptors were measured in the thymus was enlarged after orchidectomy and greatly restored in aging rats. In aging rats, both aromatase inhibitors restored the thymus, which appeared normal histologically. In addition, ATD enlarged the thymus in young intact animals. ... It is therefore possible to restore the thymus in intact aging rats without recourse to surgical or chemical castration, and such a maneuver may possibly be of use to enhance an immune system weakened by aging or disease."
Ещё недавний анализ показал что у женщин принимающих его для лечения рака груди значительно снижен риск альцгеймера и связанных деменций.
> Association Between Hormone-Modulating Breast Cancer Therapies and Incidence of Neurodegenerative Outcomes for Women With Breast Cancer
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2763234
In this cohort study of 57843 perimenopausal- to postmenopausal-aged women with breast cancer, exposure to hormone-modulating therapy (tamoxifen and aromatase inhibitors, especially exemestane) was associated with a significant decrease in the number of women who received a diagnosis of neurodegenerative disease, most specifically Alzheimer disease.
For AD, HMTs (such as estrogen therapy) have been shown to be associated with the onset of AD,34 whereas estrogen therapy has been shown to be ineffective as a treatment for those with a diagnosis of AD.35-43 Similarly, the failure of trials evaluating the use of SERMs in the treatment of AD could be due to the fact that the intervention was started past the therapeutic window for HMTs.18,44-46 Here, we show the beneficial effects of exposure to HMT as a prophylactic treatment for the potential prevention of AD.