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Diabetes: modulates metabolic pathways, improves insulin sensitivity
Fatty liver (NASH, NAFLD) - reduces hepatic inflammation
Neuropathic Pain - reduces inflammation by inhibiting NF-kB, STAT3
alleviates pain and nerve damage
Rheumatoid Arthritis - inhibits NF-kB activation
reduces secretion of IL-6 and other inflammatory cytokines,
blocks migration and invasion of RA fibroblast-like synoviocytes.
Psoriasis - inhibits keratinocyte hyperproliferation and reduces inflammation by downregulation of STAT3, NF-kB.
Airway Diseases (Asthma, Cystic Fibrosis, COPD)
Niclosamide inhibits certain Ca-activated Cl channels involved in mucus hypersecretion & bronchoconstriction (reduces mucus production & secretion.
it blocks release of mucus and inflammatory mediators which reduces bronchoconstriction.
anti-fibrotic agent for lung fibrosis - Niclosamide downregulates expression of collagen proteins and inhibits pro-fibrotic cytokines.
Endometriosis - Niclosamide targets STAT3 and NF-kB, reduces proinflammatory cytokines and reduces endometriotic lesion growth.
ALS
In vivo experimentation involving two ALS mouse models demonstrated slowed disease progression, enhanced survival rates, and reduced motor neuron loss and muscle atrophy.
At the molecular level, niclosamide inhibited dysregulated pathways such as STAT3 and mTOR, reduced gliosis, and dampened inflammatory signaling
niclosamide has shown remarkable potential by efficiently inhibiting the expression of S100A4, a Ca2+-binding protein frequently upregulated in reactive microglia and astrocytes in ALS models. This inhibition contributes to reduced microglial reactivity, cytoskeletal changes & inflammation in ALS
Systemic Sclerosis - inhibits STAT3, AKT, and Wnt/β-catenin pathways
reduced immune cell activation
reversal of skin and lung fibrosis and reduced rate of inflammation
CONCLUSION:
Ivermectin, Mebendazole and Fenbendazole are leading the repurposed drug revolution
but Niclosamide is the most promising of the other anti-parasitics!
https://x.com/MakisMedicine/status/2051024925037842901
Wojciech Pawelczyk @WojPawelczyk - Prayers up for America's Mayor Rudy Giuliani who is currently in the hospital.
The legendary NYC Mayor, who fought the NYC Mafia tooth and nail, visited Poland in 2019 when he met with the leader of then-ruling PiS party, Jarosław Kaczyński.
During his 2019 visit to Poland, Mayor Giuliani praised Poland and Kaczyński, saying: "I truly respect Jarosław Kaczyński. He's fighting for his country. He wants Poland to be truly independent. Your economy is becoming one of the strongest in Europe."
Poland will never forget those kind words of Mayor Giuliani.
https://x.com/WojPawelczyk/status/2051176431284019365
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